How dendritic cell therapy works and how it works

Dendritic cell therapy involves several steps:

1. Obtaining dendritic cells: First, blood is taken from the patient.
2. Isolation and differentiation of dendritic cells: The mononuclear cells obtained from the blood (usually precursor cells such as monocytes) are isolated in the laboratory. These cells are then differentiated into dendritic cells in vitro (in the laboratory) under special culture conditions. They are treated with certain cytokines that promote the maturation of the dendritic cells.
3. Loading with tumor antigens: The dendritic cells are then loaded with tumor antigens. This can be done by various methods, including the use of tumor cell lysates, synthetic peptides or RNA.
4. Maturation and activation: The loaded dendritic cells are further matured and activated to maximize their ability for antigen presentation and T cell stimulation.
5. Reinfusion into the patient: The loaded, matured and activated dendritic cells are returned to the patient by injection, where they activate the T cells and trigger a targeted immune response against the tumor cells.
6. Monitoring and regular check-ups: After the cell infusion, the patient is closely monitored. This includes regular check-ups, blood tests and imaging procedures to track the immune response and the progression of the cancer. Further treatments can be carried out if necessary.

Benefits of dendritic cell therapy

Dendritic cell therapy is considered a promising and innovative method of cancer treatment for several reasons. Here are some of the main reasons:

1. Targeted cancer cell attack: By using patient-specific tumor antigens, a targeted immune response is achieved against the cancer cells, making the treatment more specific and potentially more effective.
2. Long-lasting immunity: By presenting tumor antigens by dendritic cells, a strong T cell response is induced. Once activated, T cells can maintain a long-lasting immune response, reducing the risk of relapse.
3. Individualized therapy: Dendritic cell therapy can be customized for each patient by using tumor antigens specific to the patient. This increases the effectiveness of the treatment and takes into account the individual differences of the tumors.
4. Fewer side effects: Since the therapy aims to strengthen the patient's own immune system and target cancer cells, the side effects are often fewer compared to conventional cancer treatments such as chemotherapy or radiotherapy.
5. Long-term cure prospects: In some cases, dendritic cell therapy has shown impressive results, with patients achieving long-term remissions or even cures, making it a particularly attractive option in cancer treatment.

Risks of dendritic cell therapy
Although no further defensive reactions such as allergies or autoimmune reactions are expected, your doctor will carefully monitor your reaction. If such a reaction occurs, he or she will take the necessary measures. Allergic shock is theoretically possible, but has never been observed. In a single case, a patient developed rheumatoid arthritis, a type of joint inflammation, after immunotherapy.

Areas of application and clinical studies

Almost 95% of all types of cancer can be treated with dendritic cells. Whether this therapy is used alone or in combination with chemotherapy, hormone therapy or radiotherapy depends on the individual. A precise therapy concept will be worked out with your specialist. Dendritic cells are also used for diseases such as Alzheimer's disease, multiple sclerosis, COPD, type 1 diabetes and rheumatic diseases. Depending on the application, the cells are loaded with specific antigens. Numerous clinical studies have shown that the therapy is safe and has shown promising results in terms of tumor regression and survival in some patients. The therapy is constantly being researched further in order to bring patients the best possible treatment results.

An efficient therapy against cancer
The sooner you start treatment, the better your chances of success!

When conventional treatment methods no longer show therapeutic success, dendritic cell therapy is increasingly used. We now know that the immune system often functions much better in patients with a small tumor mass than in patients with a large tumor load. For this reason, we recommend having the immune system tested for its responsiveness in a special GMP procedure in the laboratory before obtaining dendritic cells. The earlier treatment is started, the higher the chances of success.

There are already promising long-term results for the particularly aggressive glioblastoma. [Study]

Treatment packages
Dendritic cell therapy is one of the most advanced forms of immunotherapy and has become increasingly important in recent years. The associated costs are an important factor, which I would like to discuss in more detail below.

1. Dendritic cell therapy (DCs) and cancer prevention (cancer vaccination)
   1-time series of applications with 2 ampoules each containing 0.2 ml of prepared and trained dendritic cell suspension.
2. Dendritic cell therapy (DCs)
   1-time series of applications with 2 ampoules each containing 0.2 ml of prepared and trained dendritic cell suspension.
3. Treatment concept “DKZplus”
   10 ampoules of ImmuSeroForte 1 VE treatment pack 46 day DNA immune build-up – apoptosis
   4-time series of applications with 2 ampoules each containing 0.2 ml of prepared and trained dendritic cell suspension.
4. Dendritic cell therapy (DCs-DKZplus) for 6-month therapy measures
   20 ampoules of ImmuSeroForte 1 VE treatment pack 46-day DNA immune build-up - apoptosis.
   6-fold application series with 2 ampoules of 0.2 ml each, with 2 blood samples prepared and trained dendritic cell suspension.
5. Dendritic cell therapy (DCs-DKZplus) for 12-month therapy measures
   30 ampoules of ImmuSeroForte 1 VE treatment pack 46-day DNA immune build-up - apoptosis
   12-fold application series with 2 ampoules of 0.2 ml each, with 3 blood samples prepared and trained dendritic cell suspension.
   Promising long-term results, especially for glioblastoma

I would be happy to give you precise information about prices in my office or over the phone! Please feel free to contact me!

Promising therapy through constant innovation

The future of dendritic cell therapy looks promising, however, as advances in immunology and cell biology are continually being made. By combining it with other forms of therapy, such as checkpoint inhibitors or CAR-T cell therapies, the potential of dendritic cell therapy could be further maximized.

Conclusion
Dendritic cell therapy is on the verge of redefining the future of cancer treatment. With its ability to precisely mobilize the immune system against cancer cells, it promises not only a more effective way to fight the disease, but also a more personalized and gentler treatment method. This innovative therapy brings fresh hope to oncology and could soon be established as a groundbreaking standard in cancer treatment. The advances in this field open up fascinating possibilities that could change the lives of many patients for the long term.